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PF 6260933 dihydrochloride
CAS No. 1883548-86-4
PF 6260933 dihydrochloride( PF 06260933 | PF-6260933 )
Catalog No. M12932 CAS No. 1883548-86-4
PF 6260933 is a potent, selective and orally bioavailable MAP4K4 inhibitor with kinase IC50 of 3.7 nM, cell IC50 of 160 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 873 | Get Quote |
|
| 50MG | 1782 | Get Quote |
|
| 100MG | 2250 | Get Quote |
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| 200MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NamePF 6260933 dihydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionPF 6260933 is a potent, selective and orally bioavailable MAP4K4 inhibitor with kinase IC50 of 3.7 nM, cell IC50 of 160 nM.
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DescriptionPF 6260933 is a potent, selective and orally bioavailable MAP4K4 inhibitor with kinase IC50 of 3.7 nM, cell IC50 of 160 nM; possesses excellent kinome selectivity and suitable properties for in vivo pharmacological characterization; significantly improves fasting hyperglycemia (44% reduction in blood glucose, 10 mg/kg, bid); also markedly reduces atherosclerotic lesion area in mice.
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In Vitro——
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In Vivo——
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SynonymsPF 06260933 | PF-6260933
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PathwayMAPK/ERK Signaling
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TargetMAP4K
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RecptorMAP4K
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Research Area——
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Indication——
Chemical Information
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CAS Number1883548-86-4
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Formula Weight369.67
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Molecular FormulaC16H15Cl3N4
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Purity>98% (HPLC)
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Solubility——
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SMILESNC1=CC=C(C2=CC(C3=CC=C(Cl)C=C3)=C(N)N=C2)C=N1.[H]Cl.[H]Cl
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Chemical Name5-(4-Chlorophenyl)-[3,3'-bipyridine]-6,6'-diamine dihydrochloride
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Ammirati M, et al. ACS Med Chem Lett. 2015 Oct 6;6(11):1128-33.
2. Roth Flach RJ, et al. Nat Commun. 2015 Dec 21;6:8995.
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